Because high blood pressure has been repeatedly produced in animals on diets deficient in cholin, 158 patients with dangerous hypertension were studied while being given cholin daily. Of this group, 133 had essential hypertension of unknown origin; and had had hemorrhages in the brain or eyes, three had diabetes, three heart disease, and 19 nephritis. Since each person had been on various medications for a year or longer without improvement, all medication was discontinued before cholin was given.